Revolutionary, minimally invasive cardiac support device and mitral valve repair technology.



The Syntach assist device is based on published research. Relevant articles are listed below.

  • Carlsson M, Ugander M, Mosen H, Buhre T, Arheden H. Atrioventricular plane displacement is the major contributor to left ventricular pumping in healthy adults, athletes, and patients with dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2007;292:H1452-9.

  • Carlsson M, Ugander M, Heiberg E, Arheden H. The quantitative relationship between longitudinal and radial function in left, right, and total heart pumping in humans. Am J Physiol Heart Circ Physiol. 2007;293:H636-44.

  • Carlsson, M. (2007). Aspects on Cardiac Pumping Department of Clinical Physiology, Lund University.

  • Toumanidis ST, Sideris DA, Papamicheal CM, Moulopoulos SD. The role of mitral annulus motion in left ventricular function. Acta Cardiol, 47(4):331-48, 1992.

  • Emilsson K, Brudin L, Wandt B. The mode of left ventricular pumping: is there an outer contour change in addition to the atrioventricular plane displacement? Clinical Physiology, 21(4):437-466, 2001.

  • Carhall C, Wigstrom L, Heiberg E, Karlsson M, Bolger AF, Nylander E. Contribution of mitral annular excursion and shape dynamics to total left ventricular volume change. Am J Physiol Heart Circ Physiol, 287(4):H1836-41, 2004.

  • Rangarajan V, Chacko SJ, Romano S, Jue J, Jariwala N, Chung J, Farzaneh-Far A. Left ventricular long axis function assessed during cine-cardiovascular magnetic resonance is an independent predictor of adverse cardiac events. Journal of Cardiovascular Magnetic Resonance, 18:3, 2016.

  • Stephensen S, Steding-Ehrenborg K, Munkhammar P, Heiberg E, Arheden H, Carlsson M, The relationship between longitudinal, lateral and septal contribution to stroke volume in patients with pulmonary regurgitation and healthy volumnteers. Am J Physiol Heart Circ Physiol 306(6):H895-903, 2014.

  • Maksuti E, Bjällmark A, Broomé M, Modelling the heart with the atrioventricular plane as a piston unit, Volume 37, Issue 1, Pages 87–92, 2015.

  • Hu K, Liu D, Herrmann S, Niemann M, Gaudron PD, Voelker W, Ertl G, Bijnens B, Weidemann F, Clinical implication of mitral annular plane systolic excursion for patients with cardiovascular disease, European Heart Journal - Cardiovascular Imaging 14, pages 205–212, 2013.

  • Willenheimer R, Cline C, Erhardt L, Israelsson B, Left ventricular atrioventricular plane displacement: an echocardiographic technique for rapid assessment of prognosis in heart failure, Heart, 78(3): 230–236, 1997.

  • Naoum C, Leipsic J, Cheung A, et al.: Mitral Annular Dimensions and Geometry in Patients With Functional Mitral Regurgitation and Mitral Valve Prolapse. JACC Cardiovasc Imaging 2016; 9:269–280.

  • Gordic S, Nguyen-Kim TDL, Manka R, et al.: Sizing the mitral annulus in healthy subjects and patients with mitral regurgitation: 2D versus 3D measurements from cardiac CT. Int J Cardiovasc Imaging 2014; 30:389–398.

  • Seemann F, Heiberg E, Carlsson M, et al.: Valvular imaging in the era of feature-tracking: A slice-following cardiac MR sequence to measure mitral flow. J Magn Reson Imaging 2019.

  • Wandt B, Bojö L, Wranne B: Influence of body size and age on mitral ring motion. Clin Physiol 1997; 17:635–46.

  • Steding-Ehrenborg K, Boushel RC, Calbet JA, Åkeson P, Mortensen SP: Left ventricular atrioventricular plane displacement is preserved with lifelong endurance training and is the main determinant of maximal cardiac output. J Physiol 2015; 593:5157–66.

  • Owen A: Effect of increasing age on diastolic motion of the left ventricular atrioventricular plane in normal subjects. Int J Cardiol 1999; 69:127–132.

  • Romano S, Judd RM, Kim RJ, et al.: Left Ventricular Long-Axis Function Assessed with Cardiac Cine MR Imaging Is an Independent Predictor of All-Cause Mortality in Patients with Reduced Ejection Fraction: A Multicenter Study. Radiology 2018; 286:452–460.

  • Ersbøll M, Valeur N, Mogensen UM, et al.: Prediction of All-Cause Mortality and Heart Failure Admissions From Global Left Ventricular Longitudinal Strain in Patients With Acute Myocardial Infarction and Preserved Left Ventricular Ejection Fraction. J Am Coll Cardiol 2013; 61:2365–2373.

  • Diller G-P, Kempny A, Liodakis E, et al.: Left Ventricular Longitudinal Function Predicts Life-Threatening Ventricular Arrhythmia and Death in Adults With Repaired Tetralogy of Fallot. Circulation 2012; 125:2440–2446.

  • Brand B, Rydberg E, Ericsson G, Gudmundsson P, Willenheimer R: Prognostication and risk stratification by assessment of left atrioventricular plane displacement in patients with myocardial infarction. Int J Cardiol 2002; 83:35–41.

  • Rydberg E, Arlbrandt M, Gudmundsson P, Erhardt L, Willenheimer R: Left atrioventricular plane displacement predicts cardiac mortality in patients with chronic atrial fibrillation. Int J Cardiol 2003; 91:1–7.

Syntach AB

Postal address: Box 4004, SE-227 21 Lund, Sweden
Visiting address: Traktorvägen 6C, SE-226 60 Lund, Sweden

+46 46 270 87 55

Syntach´s products are under development and not approved for clinical use.

© Syntach AB. All rights reserved. Syntach is a registered trademark. Privacy and cookie policy.

Designed and produced by Publiciteta&Co



We use cookies to improve your experience. By using the site, you agree that cookies are used for this purpose. Please see our privacy policy for details.